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APOE appears to have an important role in neuroplasticity and the life-long susceptibility to AD, which may be related to the generation of toxic substances66, and such toxic substances may be cleared during SWS. The question for the consideration of trazodone is whether this medication may be remedying the demise of serotonin and/or norepinephrine neurons or whether it is modulating the role of serotonin and/or norepinephrine in energy management and sleep modulation beneficially against the specific adverse effect of APOE genotype which predisposes to AD. There are many additional genetic factors which contribute small amounts to AD causation. Trazodone (trazodone) pkg. 100 mg 30 the amount of packaging.

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