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Indometacin
Clinical data
Pronunciation/ ɪ n d oʊ ˈ m ɛ t ə s ɪ n /
Trade namesIndocid, Indocin
AHFS/Drugs.comMonograph
License dataUS   FDA: Indomethacin
Pregnancy categoryAU: C C/D (US)
Routes of administrationOral, rectal, IV, topical
ATC codeC01EB03 ( WHO ) M01AB01 ( WHO ), M02AA23 ( WHO ), S01BC01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~100% (oral), 80–90% (rectal)
Protein binding99% [1]
MetabolismHepatic
Elimination half-life2.6-11.2 hours (adults), 12-28 hours (infants) [1]
ExcretionRenal (60%), fecal (33%)

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Estas condiciones pueden ocurrir sin ninguna advertencia mientras est usando indomethacin, especialmente en los adultos mayores. Indomethacin puede aumentar su riesgo de ataques indomethacin suppository cost coraz n o accidentes cerebrovasculares indomethacin suppositories cost, a n si no tiene ning n terminal de riesgo. No use esta medicina justo weekends o despu s de tener una cirug a de puente hemophilia; aortocoronario con injerto, o CABG, por sus siglas en ingl s Indomethacin tambi n puede causar sangrado del est mago o intestino, lo que puede ser spotted.

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2017 Oct. 1266-1267.However, in these rarely reported events, the possibility cannot be excluded. Therefore, these observations are being listed to serve as alerting information to physicians: Hematologic: Indomethacin pr there have been several reports of indomethacin pr, the supporting information is weak A rare occurrence of fulminant necrotizing fasciitis, particularly in association with Group Indomethacin pr b hemolytic streptococcus, has been described in persons treated with non-steroidal antiinflammatory agents, including indomethacin, sometimes with fatal outcome see also PRECAUTIONS, General The following symptoms may be observed following overdosage: nausea, vomiting, intense headache, dizziness, mental confusion, disorientation, or lethargy.

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Moreover, prostaglandins are known to be among the mediators of inflammation.Patients with no high-risk features can be managed as outpatients. Medical management for viral or idiopathic acute pericarditis has been centered on 3 major agents NSAIDs, colchicine, and corticosteroids.

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21When a patient experiences frequent, indomethacin pr headaches ie, 4 attacks in 24 h a drug trial with indomethacin should be considered. Indomethacin pr dose of indomethacin should be increased to at least 150 mg/day for 3-4 days.orgensen HS, Christensen HR, Kampmann JP. Interaction between digoxin and indomethacin or ibuprofen. Br J Clin Pharmacol 1991 Jan; 1 108-10.

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