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|Pronunciation||/ ɪ n d oʊ ˈ m ɛ t ə s ɪ n /|
|Trade names||Indocid, Indocin|
|License data||US FDA: Indomethacin|
|Pregnancy category||AU: C C/D (US)|
|Routes of administration||Oral, rectal, IV, topical|
|ATC code||C01EB03 ( WHO ) M01AB01 ( WHO ), M02AA23 ( WHO ), S01BC01 ( WHO )|
|Legal status||AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only|
|Bioavailability||~100% (oral), 80–90% (rectal)|
|Protein binding||99% |
|Elimination half-life||2.6-11.2 hours (adults), 12-28 hours (infants) |
|Excretion||Renal (60%), fecal (33%)|
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As advancing years appear to increase the possibility of adverse reactions, indomethacin should be used with greater care in the elderly see PRECAUTIONS: Geriatric Use Initial Dose: 75 mg to 150 mg daily in 3 or 4 divided doses.
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2017 Oct. 1266-1267.However, in these rarely reported events, the possibility cannot be excluded. Therefore, these observations are being listed to serve as alerting information to physicians: Hematologic: Indomethacin pr there have been several reports of indomethacin pr, the supporting information is weak A rare occurrence of fulminant necrotizing fasciitis, particularly in association with Group Indomethacin pr b hemolytic streptococcus, has been described in persons treated with non-steroidal antiinflammatory agents, including indomethacin, sometimes with fatal outcome see also PRECAUTIONS, General The following symptoms may be observed following overdosage: nausea, vomiting, intense headache, dizziness, mental confusion, disorientation, or lethargy.
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Moreover, prostaglandins are known to be among the mediators of inflammation.Patients with no high-risk features can be managed as outpatients. Medical management for viral or idiopathic acute pericarditis has been centered on 3 major agents NSAIDs, colchicine, and corticosteroids.
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21When a patient experiences frequent, indomethacin pr headaches ie, 4 attacks in 24 h a drug trial with indomethacin should be considered. Indomethacin pr dose of indomethacin should be increased to at least 150 mg/day for 3-4 days.orgensen HS, Christensen HR, Kampmann JP. Interaction between digoxin and indomethacin or ibuprofen. Br J Clin Pharmacol 1991 Jan; 1 108-10.
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Doi.Because serious GI indomethacin suppository ulcerations and bleeding can occur without warning symptoms, physicians should monitor for signs or symptoms of GI bleeding.
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