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In oral Segment I and Segment III studies in rats with Tretinoin, decreased survival of neonates and growth retardation were observed at doses in excess of 2 mg/kg/day 16 times the human topical dose adjusted for total body surface area Oral Tretinoin has been shown to be teratogenic in rats, neutrogena tretinoin, hamsters, and subhuman primates.I had also some wrinkles becoming more prominent. I felt old and ugly although I am still young turning 29 Neutrogena tretinoin I started using it, y face was red and sensitive for about 2 weeks, but now my skin adapted to it and it does not hurt anymore.
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If they do, it is just your skin adjusting to Tretinoin and this usually subsides within two to four weeks. These reactions can usually be minimized by following instructions carefully.Topical hydroquinone should be used on pregnant women only when clearly indicated.
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