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THE USE OF PROMETHAZINE PRODUCTS SHOULD BE AVOIDED IN PEDIATRIC PATIENTS WHOSE SIGNS AND SYMPTOMS MAY SUGGEST REYE'S SYNDROME OR OTHER HEPATIC DISEASES. Excessively large phenergan 50 mg injections of antihistamines, including promethazine hydrochloride, in pediatric patients may cause sudden death see OVERDOSAGE Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients.Another study in Canada by the Motherisk program looked at fetal outcomes for mothers who had taken Ondansetron as phenergan 50 mg injection as mothers who had taken other anti emetics and compared them to the baseline rate of birth defects.

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