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For patients who were previously treated with twice-daily NPH human insulin, the initial dosage of insulin glargine was reduced by 20% and was subsequently based on patient response. 01} Absorption patterns are similar after subcutaneous injection into the arm, abdomen, or leg indicating lack of injection-site dependency; however, injection sites within an injection area should be rotated with each injection.These patients should be observed for signs and symptoms of heart failure.
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