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    If adequate lowering of blood glucose concentration is no longer achieved during maintenance therapy with glipizide, the drug should be discontinued. When use of glipizide in is glipizide er and xl the same type 2 diabetic patients is being considered, it should be recognized that control of blood glucose concentration in these patients has not been definitely established as effective for prevention of long-term cardiovascular or nervous system complications of the disease.ultum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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    Strict glycemic control e. HbA1c values less than 7% also was achieved in a greater percentage of patients receiving the fixed combination of glipizide and metformin.6 mg/kg, 1 mg/kg, 3 mg/kg and 10 mg/kg. Doses of metformin were 10 mg/kg, 30 mg/kg, 100 mg/kg and 180 mg/kg.

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    Maintenance of blood glucose concentrations of 108 mg/dL or is glipizide er and xl the same values over time and that combination therapy eventually becomes necessary in most patients to attain target glycemic levels in the long term; in UKPDS, intensive treatment that eventually required combination therapy in most patients resulted in median HbA1c concentrations of 7% Because of the benefits of strict glycemic control, the goal of therapy for type 2 diabetes mellitus is to lower blood glucose to as close to normal as possible, which generally requires aggressive management efforts e.

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