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Doi. ubMed: 9708828Shen J, Carcaboso AM, Hubbard KE, Tagen M, Wynn HG, Panetta JC, Waters CM, Elmeliegy MA, Stewart CF: Iressa gefitinib roles of Iressa gefitinib cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.One might expect this to be the case given its proposed mechanism of action.
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Withhold IRESSA for severe or persistent up to 14 days diarrheasee DOSAGE AND ADMINISTRATION, ADVERSE REACTIONS. Ocular disorderskeratitis 0.pproximately 5% of IRESSA-treated patients and 2. of placebo-treated patients discontinued treatment due to an adverse event.
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The acute toxicity of gefitinib up to 500 mg in clinical studies has been low.Its only serious documented side effect is that it can cause damage to lungs in the form of interstitial lung disease.
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