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    71 CANOE Canada 4 RCTIGT207; 3. PlaceboMetformin 500 mg plus rosiglitazone 2 mg twice daily 66Principal metformin er tab prevention metformin er tabs that did not evaluate metformin Diabetes Prevention Study Finland 0 RCTIGT522; 3.From the 1950s to the 1970s, the leading drug in the biguanide class was phenformin.

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