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After discussion with my veterinarian and the veterinary behaviorist, e increased Piglet's clonazepam to 3 mg on days 7 and 14 of dosing, respectively. Accumulation of clonidine does not appear to occur following continuous epidural infusion of the drug in adult cancer patients.

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To ensure overnight blood pressure control with oral administration, the last dose of the day should be administered immediately before retiring. If oral clonidine therapy is to be discontinued, dosage of the drug should be clonidine hydrochloride 25 micrograms reduced over a period of 2-4 days to avoid the possibility of precipitating the withdrawal syndrome.Clonidine is clonidine hydrochloride 25 micrograms taken one to two times per day with or without food.

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